Abstract: With the advent of Agriculture 4.0, flue-cured tobacco cultivation is moving towards the development of smart agriculture. As a key tool in smart agriculture, unmanned aerial vehicle (UAV) multispectral imaging technology has shown significant potential in the management of tobacco fields. The widespread use of the DJI Phantom 4 Multispectral (P4M) drone in China, in particular, has laid a solid foundation for the application of this technology in tobacco industry. Here we systematically review the application of UAV multispectral imaging technology in the smart management of flue-cured tobacco fields, including monitoring of planting area and growth, yield and leaf quality prediction, nutritional diagnosis and fertilization, soil moisture monitoring, and pest and disease prediction. These technological approaches can significantly enhance the smart field management of tobacco production, optimizing resource usage and improving yield and quality. However, challenges such as high technical costs, complex data processing, and a lack of standardized operating procedures remain in practical application. Further research is required to address these issues.