Abstract: Thirteen nutrient indices of 534 soil samples from six base units, three major soil types in Guangdong Nanxiong tobacco growing areas were determined and soil fertility limiting factors were analyzed. The principal component analysis method was used in determining the weights of the indices of soil nutrients. A comprehensive evaluation was conducted by estimating the soil fertility comprehensive index of scalar values (IFI). The results showed that: (1) The purple soil showed a weak alkaline reaction, and the Niugantu soil was neutral, and the Shanitu soil showed a strong acid reaction; (2) The contents of available nitrogen and organic matter in Niugantu and Shanitu soil were higher, and those in purple soil were generally low; The content of available potassium in purple soil and Niugantu soil was higher, and the content of potassium in Shanitu soil was deficient; All 3 of soil types were rich in available phosphorus; (3) The three major soil types were lack of boron, copper, zinc and chlorine in various degrees, and rich in manganese; There is a lack of iron element in purple soil, and lack of calcium and magnesium in Shanitu soil; (4) The average integrated fertility index (IFI) of the three soil types was 0.577 with a variation coefficient of 19.25%. Xiongzhou (IFI =0.641) and Wujing (IFI =0.655) base units showed higher soil integrated fertility indices while the other base units had "medium" IFI (0.6 > IFI > 0.5); (5) The IFI of Niugantu soil fertility (0.649) was higher while that of Shanitu soil (0.574) and purple soil (0.495) were lower.