Abstract: The purpose of this study was to evaluate the effect of black frame toad predation on tobacco insect control. The experiment was to investigate the types and quantity of insects in the tobacco field in Puer, and to analyse the relationship between common tobacco pests and black frame toad feeding habit. After putting in black frame toads, we investigated the types and quantity of diseases and insects, damage of the plants, pesticides and heavy metals in I on tobacco leaves and in the soil. Results from independent samples were analyzed with t test. The results showed thatthe predation of black frame toad is of wide range, including all types of insects in the tobacco field. The major pests in the tested field were Prodenia litura and Clanis bilineata. The density of Prodenia litura in the black frame toad treated field non-treated field was 1.39 and 0.09 zhi/m² respectively. Clanis bilineata was 0.41 and 0.09 zhi/m² in treated and non-treated field, respectively. The density of both the 2 insects in control field was significantly higher than that in the treated field. As and CD were 117.45 and 2.34 mg/kg in the control field, 10.30 and 0.37 mg/kg in the treated filed. As and CD were both significantly higher in control fields than in treated fields. Tobacco disease was not severe in the fields. In conclusion, the predation of black frame toad can be used in controlling insects to reduce pesticide usage in tobacco fields.