Abstract: To explore effective protective agents of stored tobacco, the toxicity of seven kinds of pesticides: Deltamethrin (98.5%), Cyhalothrin (97.1%), Betacyfluthrin (27%), Emamectin benzoate (66.67%), Fenvalerate (65.9%), Avermectins (8.08%), Pririmiphos-methyl (90%) against cigarette beetle (Lasioderma serricorne) were tested. The results showed that: the toxicity of Cyhalothrin (97.1%) to the larvae of cigarette beetle was the highest, the LD50 of Cyhalothrin was 2.91061 mg/L. Followed by Deltamethrin (98.5%), Betacyfluthrin (27%), Pririmiphos-methyl (90%), Fenvalerate (65.9%). The lowest toxicity to the larvae of cigarette beetle was Emamectin benzoate (66.67%). The highest toxicity to the adults of cigarette beetle was Pririmiphos-methyl (90%) among the four kinds of pesticides tested.