Abstract: Cultivation of low-hazard-tobacco (Nicotiana tabacum L.) has been focus of research on tobacco sciences. Recently, numerous studies indicated that cadmium accumulation by tobacco in polluted soils was becoming one of the main factors that affecting the tobacco quality. Cadmium was readily accumulated by crops such as tobacco in soils, and the cadmium stress in soils could not only affect the physiological process, but also reduced tobacco’s quality. The mechanisms governing the transport, accumulation, and compartmentalization of cadmium by tobacco are reviewed in this paper and some integrated approaches to reduce the uptake of cadmium by tobacco are introduced for further study.