Abstract: To explore the relationship between agronomic and economic characters of flue-cured tobacco in Enshi tobacco-growing areas, and identify the major impact factors of tobacco economic character, the correlations between agronomic and economic character of tobacco under three fertility levels were determined by use of grey correlation analysis. The results showed that the leaf yields and output value affected strongly by plant height and leaf number under high fertility level, the stem thickness, the upper leaf area and middle leaf area also affected leaf yields and output value. The grey correlation degree was high between the stem thickness and leaf yields and output value, average price of flue-cured tobacco under middle fertility level. The leaf number, the middle leaf area and plant height also had a high grey correlation degree. The distance between internodes were an important impact factor on leaf yields, output value and proportion of superior leaves of flue-cured tobacco under low fertility level and the leaf number was also an impact factor. These results are significant for improving production technical measures and increasing economic values of flue-cured tobacco in Enshi tobacco-growing areas.