Abstract: In order to decrease the lead and cadmium contents in tobacco leaves, and improve the safety of tobacco and tobacco products, pot experiments were conducted to study the effects of different types of organic fertilizers on the growth and the heavy metal contents of the flue-cured tobacco. The results showed that under the same condition, applying organic and inorganic fertilizer remarkably improved plant height, maximum leaf area and biomass at late growth stage. Compared with the CK, The application of commercial organic fertilizer significantly decreased leaf lead content by 43.83%, and application of farmyard manure significantly decreased leaf cadmium content by 33.29%. The content of lead in tobacco plants varied in the sequence of roots>leaves>stems, while cadmium followed the sequence of leaves>stems>roots. 46.48% ~ 60.91% of lead was found in the roots, while 78.03% ~ 81.39% of cadmium was found in the leaves.