Abstract: The characteristics of tobacco virus disease in Shandong tobacco planting regions were analyzed. Possible occurances of tobacco virus disease in next fews years were predicted. The prevention and control methods for the disease were suggested. The major prevention and control measures include variety improvement, entironmental factor improvement, field operation improvement, and cropping sustme optimizing, plus low toxic and residual pesticide application. The key is to prevention, and prevention and control comprehensively.