Abstract: The field experiment using slow release fertilizer, growth regulator and irrigation in mature stage revealed that Slow release potassium K1 could enhance potassium adsorption of tobacco plants, increase the plant height, the length of internode and leaves, improve the resistance to weather fleck, wild fire disese, TMV and CMV, and enhance aroma quality, combustibility and ash color. The brassinolide used in fast growth period could decrease the wild fire disease index and content of chlorine in tobacco leaves, and improve the first grade leaf proportion, average price, yields and economic value. The irrigation in mature stage could decrease the content of chlorine, but tobacco diseases were more serious.